© 2009 The Royal College of Psychiatrists
OPEN ACCESS ARTICLE
Outcomes of people with psychotic disorders in a community-based rehabilitation programme in rural India
Sangath, Goa, India, and London School of Hygiene and Tropical Medicine, UK
Sangath, Goa, India, and Mailman School of Public Health, Columbia University, New York, USA
Centre for Behavioural and Social Sciences in Medicine, Department of Medicine, University College London, UK
Department of Social Medicine, Harvard Medical School, Boston, Massachussetts, USA
Sangath, Goa, India, and London School of Hygiene and Tropical Medicine, UK
Correspondence: Professor Vikram Patel, Sangath Centre, Porvorim, Goa, India 403521. Email: vikram.patel{at}lshtm.ac.uk
S.C. and V.P. are associated with a randomised controlled trial evaluation of the community-based rehabilitation intervention described in this paper, funded by the Wellcome Trust.
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Background
There is little evidence of the feasibility, acceptability and impact of services for the care of people with psychotic disorders in low- and middle-income countries.
Aims
To describe the scaling up and impact of a community-based rehabilitation programme for people with psychotic disorders in a very-low-resource setting.
Methods
Longitudinal study of people with psychotic disorders who had been ill for an average of 8 years in a rural Indian community. All individuals received a community-based intervention package comprising psychotropic medications, psychoeducation, adherence management, psychosocial rehabilitation and support for livelihoods. The primary outcome was change in disability scores.
Results
The cohort consisted of 256 people with psychotic disorders (schizophrenia, bipolar affective disorder and other psychosis) of whom 236 people completed the end-point assessments (92%), with a median follow-up of 46 months. There were significant reductions (P<0.05) in the levels of disability for the cohort, the vast majority (83.5%) of whom engaged with the programme. On multivariate analyses, lower baseline disability scores, family engagement with the programme, medication adherence and being a member of a self-help group were independent determinants of good outcomes. Lack of formal education, a diagnosis of schizophrenia and dropping out of the programme were independent determinants of poor outcomes.
Conclusions
Community-based rehabilitation is a feasible and acceptable intervention with a beneficial impact on disability for the majority of people with psychotic disorders in low-resource settings. The impact on disability is influenced by a combination of clinical, programme and social determinants.
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Although repeated calls have been made for accessible, equitable, acceptable and effective services for people with severe mental disorders,1 a persistent and unacceptably large treatment gap remains for these conditions in low- and middle-income countries.2 Even though evidence-based packages of care for these disorders have been identified,3 the actual delivery of treatments in resource-constrained settings remains a challenge4 and is a global mental health priority.5 One of the most important barriers to appropriate service provision to people with persistent psychotic disorders is the lack of adequately trained specialist mental health personnel.6 Non-specialist, low-cost human resources are essential to implement public health-oriented services in low- and middle-income countries where specialist resource constraints are likely to continue.7 One such method is community-based rehabilitation where services are provided in close collaboration between specialists and locally available personnel, within an explicit human rights and developmental framework.8 We have previously reported on the efficacy of community-based rehabilitation for people with chronic schizophrenia in a rural area of India compared with routine out-patient care.9 Although community-based rehabilitation approaches are being more widely implemented in low- and middle-income countries,10 their acceptability, impact on social outcomes of service users, and determinants of these outcomes are inadequately described.
We describe the uptake and impact of a service using the community-based rehabilitation framework for people with psychotic disorders within a defined catchment area in a rural, impoverished community in India. The programme was implemented by the Ashagram Trust, a community-based nongovernmental organisation. We describe the functional (disability) outcomes of people with psychotic disorders; identify the determinants of their outcomes; and highlight the research and policy implications of this study for service provision in rural areas of low- and middle-income countries.
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Setting
The community-based rehabilitation programme was implemented in the administrative ‘block’ (subdistrict) of Pati, which is located in the district of Barwani in the state of Madhya Pradesh, India. Pati has a population of 125 463 living in 106 villages, as per the 2001 census (www.censusindia.gov.in). The majority (92.6%) of the people are ‘scheduled tribes’ (official government terminology for the indigenous people of India) who are dependent on seasonal agriculture and animal husbandry. Pati is one of the most underdeveloped areas in India with 82.6% living below the poverty line (defined as the cost of an average Indian food consumption basket amounting to 2400 calories/day for rural areas; this translates approximately into $2USD/day at current monetary rates). Prior to the rehabilitation programme, there were no mental health services in Pati.
Sample
Our previous rehabilitation
programme9 was the
template for the scaled up services in Pati. Services were provided to people
with a broad range of mental disorders, viz. psychotic and common
mental (depression and anxiety) disorders, epilepsy and intellectual
disability. In this paper, we describe the outcomes of people with psychotic
disorders – schizophrenia, bipolar disorders and ‘other’
psychotic disorders – who had experienced at least 6 months of the
illness and had been enrolled in the programme for a minimum of 12 months,
over a total median period of 46 months.
The intervention
To improve access to the population living in isolated locations, the
community teams were based in four different ‘clusters’. Each
cluster consisted of four to five community-based rehabilitation workers
supervised by a cluster coordinator. The rehabilitation workers received an
initial 4-week training programme comprising modules covering the recognition
and management of people with mental disorders (details of the training
programme are available from S.C.). A continuing supervision process during
the weekly meetings with the cluster coordinators, during monthly team
meetings with the programme psychiatrist and during the psychiatrist’s
visit to the outreach camps was followed to improve and sustain the skills of
these rehabilitation workers during the programme. The overall structure,
personnel and their key roles in the programme are shown in online Fig.
DS1.
Specialist care was provided by a psychiatrist through monthly outreach camps in each of the clusters. Usually arranged in a primary health clinic, these camps were held on a predesignated day of the month known to service users. In these camps, both new referrals and those being followed up were assessed, and drug treatments prescribed. Second-generation oral antipsychotic medication (risperidone and olanzapine) was the preferred choice since there are no significant cost differences between these and the first-generation antipsychotic medications in India. Selective serotonin reuptake inhibitors (fluoxetine and sertraline) were the most commonly used antidepressants, and mood stabilisers (lithium and carbamazepine) were used as necessary. Whenever clinically appropriate, depot antipsychotics (zuclopenthixol decanoate) and benzodiazepines (e.g. clonazepam, lorazepam) were also utilised. The individual components of the programme are described in online Table DS1. Self-help groups, comprising service users and community members, focused on livelihood support through microcredit facilities and social reintegration.
Data collection
Enrolment of participants in the community-based rehabilitation programme
was initiated in September 2001 and the end-point assessment was conducted
between May and August 2006. Data for each participant were collected at the
point of programme entry and at the time of the end-point assessment. Verbal
consent (in view of the very low literacy rates in the area) from both the
participant and key family members was obtained routinely before the end-point
data collection.
Primary outcome
The primary outcome was the change in disability scores between entry into
the programme and at end-point. This was assessed using the Indian Disability
Evaluation Assessment Scale
(IDEAS).11 The
IDEAS, which is scored after a semi-structured interview with the primary
caregiver, measures disabilities in four domains: self-care, interpersonal
activities, communication and understanding, and work. The global score
generates four categories of disabilities (from none to severe).
Process indicators
Adherence to medication was coded as either complete, intermittent (total
duration of non-adherence <90 days in a year) or non-adherent (
90 days
in a year of not taking medication). These categories were generated from the
tertiles of the distribution of adherence data. For analysis, those with
complete and intermittent adherence were combined into one category of
adherence. Adherence was recorded by programme staff during home visits; since
all participants were living with families who were intimately involved in
their treatment, ratings were made in consultation with caregivers to provide
reliable information. Participants who did not adhere to medication were asked
to identify the most important reason for not continuing with treatment; the
three most common responses were lack of money, preventing them from accessing
the monthly camps to pick up medications; lack of information about the camps;
and medication-related problems (lack of improvement, or side-effects). Each
of these was rated as a dichotomous variable. Participants were rated as
having dropped out of the programme when they did not engage with the
programme and refused further services; all other participants (including
those who had been discharged in a planned manner) were considered to be
engaged with the programme. Participants were considered as members of the
self-help groups if they had formally enrolled themselves and had attended at
least two of the previous 6 monthly meetings. These data were extracted from
the clinical records and verified by the respective cluster coordinator.
Other baseline measures
At the time of the initial assessment, the psychiatrist recorded
participants’ diagnoses using ICD–10
criteria12 –
the category of ‘other psychoses’ included those with
schizoaffective disorder, delusional disorder, substance-induced chronic
psychotic disorders and psychosis not otherwise specified. Duration of illness
and other historical information were elicited from family care providers. All
families were specifically asked whether lack of money to access treatment or
treatment discontinuation was a reason why their family member had remained
ill prior to engagement with the programme. During this initial engagement,
the cluster coordinator made a global rating of the support provided to the
participant by their family based on:
- whether the person was being helped to complete activities of daily
living
- whether the person was encouraged to have some interactions within the
family
- whether the family had made any effort to provide treatment in the previous
12 months
- whether the family were using any physical restraints on a regular
basis.
If families did not provide any meaningful help despite having people in the house to do so, did not encourage interactions, had made no attempt to seek treatment (traditional healing or medical care) in the previous 12 months or were using physical restraints, they were rated as providing poor family support. The rehabilitation workers also collected sociodemographic and economic data from participants and their family using a modified version of a questionnaire that has been used in rural India (available from the authors on request).
Other end-point measures
To generate locally relevant measures of social outcomes for end-point
assessment, we conducted focus group discussions with the community team,
service users and selected self-help group members to identify a list of
social activities that the community usually participated in. From this
initial list, we compiled the most commonly cited items, such as attending
festivals, marriages or working regularly, and rated them as dichotomous
responses. We also generated a list of assets which families had acquired
during the course of the intervention that could be reliably assessed; this
included livestock, farming equipment, home appliances and home improvement
activities. The list of gains in household assets was combined into a
dichotomous composite variable, any asset gained after programme. At
end-point, the rehabilitation workers recorded their global assessment of the
quality of the family’s engagement with the programme based on the
quality of the therapeutic alliance, engagement in psychoeducation sessions,
their partnership in implementing care plans, supervision of adherence,
encouraging social interactions outside of the home environment, emotional
support for the person with the illness and participating in local self-help
group activities. Families were rated as supportive if they met at least three
of these criteria.
Analysis
The primary outcome measure was the change in IDEAS scores between baseline
and end-point. The changes in scores were converted into three categories:
minimal improvement (<20% change from baseline), moderate improvement
(20–40% change from baseline) and marked improvement (41% change
from baseline). These were determined a priori based on previous
clinical experience and analysis of disability data from our earlier
work.9
For the analysis of the determinants of outcomes, we analysed three broad domains of interest: baseline sociodemographic variables, clinical variables recorded at the time of enrolment and process indicators. Analysis of covariance (ANCOVA) was used for estimating associations between independent variables and the primary outcome measure. The baseline IDEAS score was used as a covariate in the analysis which generated the regression coefficient (β) derived from the ANCOVA. All analyses were a priori adjusted for age and gender. A stepwise approach was then used to identify the determinants of outcomes. First, the univariate association of each domain of variables was estimated. In the second step, variables found to be associated at a level of significance of P<0.05 in the univariate analyses were included in domain-specific multivariate analyses. This identified the variables independently associated with the outcome within each of these domains. Finally, the significant variables from the domain-specific analyses were entered in a multivariate model to identify the variables that independently predicted outcomes for this cohort. Statistical analyses were performed using Stata version 9 for Windows. Missing values were not imputed.
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A total of 256 people with psychotic disorders were enrolled in the programme, for 236 (92.2%) of whom we were able to complete end-point assessments. The median duration of follow-up was 46 months (range 12–52). Of the 20 people for whom end-point data were unavailable, 11 (4.3%) had died, of whom 6 had died by suicide. Five people had migrated from the study area and four participants and their families refused to be interviewed for the end-point assessments.
Sample characteristics
Members of scheduled tribes comprised 86.9% of the cohort, and 84.7% of the
families in the programme were living below the poverty line. Overall, 74.2%
of the cohort were aged 20–45 years, with males comprising 55% of the
sample. Although 172 (67%) participants were married, 25 (9.7%) were separated
as a result of the psychotic illness. In total, 78.5% of the cohort had not
received any formal education, and 57% were living in joint families. People
with schizophrenia (n = 142, 55.5%) constituted the largest
proportion of the cohort; bipolar affective disorder was diagnosed in 71
people (27.7%) and those with other psychoses constituted the remainder
(n = 43, 16.8%). On average, participants had been ill for 8 years
and had a high level of disability (Table
1). Poverty was cited by over a third of participants (36%) as the
most important reason that limited access to treatment before enrolment in the
rehabilitation programme. Overall, 31% of families were rated as not being
supportive; poor family support was correlated with increasing duration of
illness and a diagnosis of schizophrenia. At baseline, people with
schizophrenia had relatively higher levels of disability and were
significantly more likely to be separated from their spouses and families
compared with other diagnostic groups
(Table 1).
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Table 1 Baseline characteristics of the sample disaggregated by
diagnosisa
(n = 236)
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Process indicators
In the initial 2 years, approximately 80% of referrals to the programme
were made by rehabilitation workers. In contrast, the self-help groups emerged
as the single largest (80%) source of referrals in the last 2 years of the
programme (Fig. 1).
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Fig. 1 Referral pattern of the community-based rehabilitation programme over
time.
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At the time of the end-point assessment, there were 55 self-help groups with regular within-group microcredit activities; some of these had established linkages with banks and the local government to access funds for assistance with livelihood programmes such as horticulture and water conservation. Overall, 155 (65.7%) participants were registered as members of these self-help groups.
Prevalence of primary outcomes
Marked improvement in IDEAS scores was reported for 50% (95% CI
43.7–56.3; n = 118) of participants, and 40% (95% CI
34.2–46.6; n = 95) showed moderate improvement. The remaining
10% (95% CI 6.5–14.2; n=23) showed minimal improvement.
Social outcomes and their association with end-point disability
The social outcomes of the cohort, assessed at end-point, indicated that
the majority of participants had been taking part in normative community
activities such as attending marriages (82.6%), participating in community
festivals (81.3%) and visiting relatives in another village (84.3%). Most
participants had also exercised their rights as citizens by attending the
gram sabha or village development council meetings (64.7%) and voting
in village elections (75.2%). The most common economic asset (63%) gained by
families during the course of the programme was additional livestock, followed
by home appliances such as a bicycle (26%); 68.2% also secured employment in
the National Rural Employment Guarantee (NREG) scheme. This assured the
families of those living below the poverty line of employment, on stipulated
minimum wages, for at least 100 days a year in local development work.
Bivariate analyses indicated that all of these social measures – attending community festivals (β = 0.61, P<0.001); attending marriages (β = 0.82, P<0.001); visiting relatives (β = 0.84, P<0.001); attending gram sabhas (β = 0.60, P<0.001); voting in local elections (β = 0.59, P<0.001); acquiring new economic assets (β = 0.61, P<0.001); and access to the NREG (β = 0.67, P<0.001) – were closely correlated with the primary outcome. This confirms that the measures of disability and social functioning overlap significantly. These findings also suggest convergent validity of our primary outcome.
Determinants of outcome
Among the sociodemographic factors at entry, univariate analyses indicated
that being married was associated with better outcome, whereas not having
received any formal education, lack of family support and poverty limiting
access to care before enrolment in the programme predicted a poorer outcome.
Of the baseline clinical variables, the diagnosis of schizophrenia, an
increasing duration of the illness and a higher baseline IDEAS score predicted
poor outcomes (Table 2). On
multivariate analysis, the diagnosis of schizophrenia, lack of formal
education, lack of family support and being separated emerged as independent
predictors of poor outcome.
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Table 2 Baseline sociodemographic and clinical variables predicting
outcomea
(n = 236)
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The univariate analyses of the process indicators indicated that dropping out from the programme was associated with poor outcome, whereas medication adherence, active membership in self-help groups and families engaged with the programme were determinants of good outcomes (Table 3). Multivariate analysis of the process indicator domain showed that all these variables remained independently associated with outcome.
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Table 3 Programme determinants of
outcomesa
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The final multivariate analysis identified lower baseline disability, adherence to prescribed medications, having a family engaged with the programme and being a member of a self-help groups as independent predictors of good outcomes. On the other hand, having a diagnosis of schizophrenia, not having any formal education and dropping out of the programme were independent predictors of poorer outcome.
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Outcomes and affective components of community-based rehabilitation
Psychotic disorders pose a substantial burden of disability in low- and middle-income countries13 and providing effective, affordable and acceptable services in resource-constrained settings is a global mental health priority.5 The Pati programme demonstrates that service provision is feasible in such a setting with a cadre of local community health workers being frontline care providers. The programme was acceptable to service users as indicated by the high level of engagement over nearly 4 years of follow-up, the involvement and endorsement of the programme by the community and increasing referrals from community-based self-help groups in the later years of the programme (Fig 2). The programme facilitated the social participation of people with psychotic disorders and helped address their economic concerns through linkages with existing employment schemes and microcredit facilities. Social disadvantage (as indicated by lack of education) and inadequate family engagement with the programme predicted poorer functional outcomes, as reported from another long-term outcome study in India.14
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Table 4 Final multivariate model of independent variables associated with
improvement (n=236)
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Two components of the community-based package emerged as being independent predictors of favourable outcomes: adherence to psychotropic medication and participation in self-help groups. Medication adherence has recently been demonstrated to be effective in reducing disability in a community cohort of people with schizophrenia in rural India.15 A combination of methods, accessible and home-based services, psychoeducation, enlisting family and community support, were used to promote adherence and engagement with services. There are close conceptual similarities of the inclusive community-based rehabilitation services in this programme and the capability-oriented recovery approach.16
Our study adds to the limited evidence17 on the impact of community-oriented service delivery models for people with psychotic disorders in low- and middle-income countries in three respects. First, our results add to the evidence that the community-based rehabilitation approach is a feasible and acceptable model of service provision for people with psychotic disorders in a particularly challenging rural setting in India. Second, the study provides a template of the structure, content and process of service delivery that can be replicated. Finally, the results underline the benefits of health programmes engaging with local communities to maximise restoration of social roles of people with psychoses. In this case, access to microcredit facilities through self-help groups in Pati had mutual benefits for service users and the community. The self-help groups were the structural basis of community support and members of the group took an increasingly active role in making referrals to the programme, supported and gave practical assistance to families, and made preferential loans to people recovering from their illness to improve their livelihoods. Most importantly, these groups supported the social inclusion of people with psychosis in mainstream community activities and reduced discrimination. The community-based rehabilitation service was also reasonably successful in addressing some of the common barriers to equitable access in health programmes such as female gender, poverty and belonging to a disadvantaged social group.
Policy and research implications
Our study has a number of strengths that partially offset some of its
limitations (see below). First, the study shows the importance and feasibility
of monitoring routine process and outcome data in mental health services using
existing human resources. Second, we have reported outcomes over a median of 4
years, the longest such period of follow-up of a health service programme from
any low- and middle-income country. Third, the high rates of end-point
assessments ensure that the findings are not compromised by attrition bias.
Fourth, unlike previous studies, which have focused on schizophrenia
exclusively, this study describes the outcomes for people with a range of
chronic psychotic disorders, which is more relevant for programme planning and
implementation. Finally, in contrast to most existing studies, which define
outcomes using clinical measures, we used broader outcome measures related to
function, which were culturally valid and locally generated.
There are important policy and research implications of this programme for the planning of community services for people with severe mental disorders in low- and middle-income countries. The results provide evidence that community-based rehabilitation programmes relying primarily on non-specialist health workers are acceptable and feasible, and have an impact on the social and economic functioning of people with psychotic disorders and their families. The most important limitation of our study is that, by being derived from the monitoring and evaluation of an ongoing community mental health intervention rather than a controlled clinical trial evaluation, we are unable to comment on the effectiveness of the intervention. Furthermore, the findings are nested in the particular social and cultural milieu of the tribal community in Pati; the unique challenges and opportunities for the programme may not necessarily generalise to other settings easily. These limitations will be addressed through an ongoing controlled clinical trial of the interventions in two diverse settings in India, currently in progress. We propose that, based on the evidence accrued so far, community-based rehabilitation is a promising approach to closing the treatment gap for people with severe mental disorders in low- and middle-income countries.
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This programme was partly supported by the Sir Dorabji Tata Trust, a registered charity in Mumbai, India. V.P. is supported by a Wellcome Trust Senior Clinical Research Fellowship in Tropical Medicine.
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We thank the Pati programme staff, in particular, the then Programme Director, Dr Ashish Gupta, for their support in conducting the programme and in recording the data meticulously. We would also like to thank the management of Ashagram Trust for allowing us to conduct the study. Finally, we are deeply indebted to the participants, their families, the self-help group members and the communities where the programme was conducted for their support and generosity during the data collection process.
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