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The British Journal of Psychiatry (2002) 181: s30-s37
© 2002 The Royal College of Psychiatrists

Subjective and objective neuropsychological abnormalities in a psychosis prodrome clinic*

MARTIN HAMBRECHT, MD, MICHAEL LAMMERTINK, MD, JOACHIM KLOSTERKÖTTER, MD, EVELINE MATUSCHEK, MA and RALF PUKROP, PhD

Department of Psychiatry and Psychotherapy, University of Cologne, Germany

Correspondence: Professor Martin Hambrecht, Klinik für Psychiatrie und Psychotherapie, Evang. Krankenhaus Elisabethenstift, Landgraf-Georg-Str. 100, 64287 Darmstadt, Germany. E-mail: hambrecht.martin{at}krankenhaus-elisabethenstift.de

Declaration of interest Funded by the Cologne Faculty of Medicine (Köln Fortune) and Federal Ministry for Education and Research BMBF, German Schizophrenia Research Network (grant 01 GI 993x).

* Presented in part at the European First Episode Schizophrenia Network Meeting, Whistler BC, Canada, 28 April 2001.

Background Predicting transitions to psychosis is difficult. Neuropsychology might facilitate predictions.

Aims To report preliminary data on self-perceived and objectively measurable neurocognition in prodromal patients of the first German early recognition centre.

Method Subjective neuropsychological disturbances were assessed in 51 patients with potentially prodromal symptoms of schizophrenia. Initial neurocognitive functioning was compared with matched normals and patients with schizophrenia.

Results Self-perceived deficits mostly concerned perception, cognition and stress reactivity. Five transitions happened during the 15-month follow-up. Recently emerging or intensifying deficits were to some extent predictive of transition. Persons at risk performed worse than controls on objectively measured verbal capacity, attention and memory functions.

Conclusions Neuropsychological deficits, either self-perceived or objectively measured, characterise persons at risk for schizophrenia and may contribute to predicting transitions.




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