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The British Journal of Psychiatry 151: 337-340 (1987)
© 1987 The Royal College of Psychiatrists

A controlled comparison of fluoxetine and amitriptyline in depressed out-patients

JP Young, A Coleman and MH Lader
St Thomas's Hospital, London.

Fluoxetine, a selective serotonin uptake inhibitor (mean dose 73 mg each morning) was compared with amitriptyline (mean dose 122 mg at night) in a double-blind study of 64 depressed out-patients. Fifty patients completed the 6-week trial. The drugs did not differ with respect to psychiatrists' ratings, but amitriptyline was slightly superior with respect to patients' ratings. The amitriptyline-treated group had complaints of dry mouth and dizziness on standing; the fluoxetine-treated group of sleep disturbances, nausea, and headaches.


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Copyright © 1987 The Royal College of Psychiatrists.