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The British Journal of Psychiatry 151: 288-301 (1987)
© 1987 The Royal College of Psychiatrists

Pathology, phenomenology and the dopamine hypothesis of schizophrenia

PJ McKenna
Academic Department of Psychiatry, University of Leeds.

The dopamine hypothesis of schizophrenia implies that positive schizophrenic symptoms should be understandable by reference to brain structures receiving a dopamine innervation, or in terms of the functional role of dopamine itself. The basal ganglia, ventral striatum, septo-hippocampal system, and prefrontal cortex, sites of mesotelencephalic dopamine innervation, are examined and it is argued that their dysfunction could form the basis of particular schizophrenic symptom classes. The postulated involvement of dopamine in reinforcement processes might further assist such interpretations. This type of analysis can be extended to other categories of schizophrenic psychopathology.


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Copyright © 1987 The Royal College of Psychiatrists.