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The British Journal of Psychiatry 151: 195-199 (1987)
© 1987 The Royal College of Psychiatrists

Hereditary agoraphobia and obsessive-compulsive behaviour in relatives of patients with Gilles de la Tourette's syndrome

DE Comings and BG Comings
Department of Medical Genetics, City of Hope Medical Center, Duarte, California 91010.

We present 11 pedigrees in which a propositus with Gilles de la Tourette's syndrome had first or second-degree relatives with obsessive- compulsive behaviour or agoraphobia with panic attacks, but only partially expressed the TS gene (i.e. had only motor tics or vocal tics, or neither). Of 90 females over the age of 18 presenting with TS, or with motor or vocal tics alone, nine had severe agoraphobia with panic attacks. There may be genetic subtypes of both obsessive- compulsive disorder and agoraphobia with panic attacks that are due to partial expression of the TS gene.


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Tics in Tourette Syndrome: New Treatment Options
J Child Neurol, May 1, 1999; 14(5): 316 - 319.
[Abstract] [PDF]


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Copyright © 1987 The Royal College of Psychiatrists.