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The British Journal of Psychiatry 150: 685-689 (1987)
© 1987 The Royal College of Psychiatrists

Lithium in the treatment of aggression in mentally handicapped patients. A double-blind trial

M Craft, IA Ismail, D Krishnamurti, J Mathews, A Regan, RV Seth and PM North
Bryn-y-Neuadd Hospital, Llanfairfechan.

In a double-blind trial lasting 4 months in 42 mentally handicapped patients, the effect of lithium on aggression was assessed in comparison with placebo. In the lithium-treated group, 73% of patients showed a reduction in aggression during treatment. There were significant differences in mean weekly aggression scores and in the frequency of aggressive episodes between the lithium and placebo groups. Side-effects were noted in 36% of the lithium group (and 20% of the placebo group), but were mainly transitory. There were no episodes of toxicity, and no patients had to be withdrawn from the trial. Lithium appears to be worth a 2-month trial in such patients, where repeated aggression has not been relieved by more appropriate placement, occupation or company.


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