The British Journal of Psychiatry 150: 526-532 (1987)
© 1987 The Royal College of Psychiatrists
An American validation study of the Newcastle Diagnostic Scale. II. Relationship with clinical, demographic, familial and psychosocial features
M Zimmerman, W Coryell, B Pfohl and D Stangl
University of Iowa Hospitals and Clinics, Department of Psychiatry, Iowa City 52242.
We completed the Newcastle Diagnostic Scale on 152 unipolar depressed
in-patients: its validity was supported by the findings that endogenous
depressives were, in contrast to neurotic depressives, older, more severely
depressed, with better social support, fewer life events, less personality
disorder, and a lower morbid risk of alcoholism and antisocial personality
in their first-degree relatives. The relationship between Newcastle scores
and the morbid risk for alcoholism was non-linear, such that a cut-off
score of 4, rather than 5, maximised the difference between the endogenous
and neurotic groups with respect to familial alcoholism rates as well as
other validating variables.