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The British Journal of Psychiatry 149: 726-733 (1986)
© 1986 The Royal College of Psychiatrists

Interactions between procyclidine and neuroleptic drugs. Some pharmacological and clinical aspects

JS Bamrah, V Kumar, J Krska and SD Soni

Procyclidine was administered to 25 chronic psychotic inpatients, stabilised on chlorpromazine, haloperidol or fluphenazine decanoate injection. We observed a significant reduction in mean serum levels of all three neuroleptic drugs which was reversed on stopping procyclidine and was inversely correlated with mean serum procyclidine levels. No significant alterations occurred on the BPRS scores or in serum prolactin levels throughout the study in any of the three groups. Possible mechanisms of this interaction and its clinical relevance are discussed.


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J.S. Bamrah, J. Krska, and S. D. Soni
Relationship between extrapyramidal symptoms and serum anticholinergic levels in treated chronic schizophrenics
J Psychopharmacol, January 1, 1988; 2(1): 39 - 46.
[Abstract] [PDF]


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Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1986 The Royal College of Psychiatrists.