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The British Journal of Psychiatry 148: 676-679 (1986)
© 1986 The Royal College of Psychiatrists

Electrocardiogram changes and therapeutic desipramine and 2-hydroxy- desipramine concentrations in elderly depressives

SP Kutcher, K Reid, JD Dubbin and KI Shulman

ECG parameters in elderly depressed in-patients were assessed during routine desipramine treatment. Significant changes (prolonged PR and PRS intervals and a decreased QTc interval) were found, related only to steady state concentrations of desipramine's major metabolite--2- hydroxy-desipramine. Potentially clinically significant changes developed in 40% of the patients. All serum drug concentrations were within therapeutic limits. Previous assurances about desipramines's cardiac safety in the elderly may need to be re-evaluated.


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F. E. Lotrich and B. G. Pollock
Aging and Clinical Pharmacology: Implications for Antidepressants
J. Clin. Pharmacol., October 1, 2005; 45(10): 1106 - 1122.
[Abstract] [Full Text] [PDF]


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Copyright © 1986 The Royal College of Psychiatrists.