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The British Journal of Psychiatry 148: 447-452 (1986)
© 1986 The Royal College of Psychiatrists

A double-blind gluten-free/gluten-load controlled trial in a secure ward population

DN Vlissides, A Venulet and FA Jenner

A double-blind control trial of gluten-free versus a gluten-containing diet was carried out in a ward of maximum security hospital: 24 patients were studied for 14 weeks. Most suffered from psychotic disorders, particularly schizophrenia. Various dimensions of behaviour were rated on the Psychotic In-Patient profile (PIP) at different stages. There were beneficial changes in the whole group of patients between pre-trial and gluten-free period in five dimensions of the PIP, maintained during the gluten challenge period; these changes could be attributed to the attention the patients received. Two patients improved during the gluten-free period and relapsed when the gluten diet was reintroduced.


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Copyright © 1986 The Royal College of Psychiatrists.