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The British Journal of Psychiatry 148: 66-69 (1986)
© 1986 The Royal College of Psychiatrists

Dexamethasone concentrations and the dexamethasone suppression test in psychiatric disorders

H Morris, V Carr, J Gilliland and M Hooper

The dexamethasone suppression test (DST) has been widely used in psychiatry as a laboratory aid for the diagnosis of endogenous depression; failure to suppress serum cortisol levels is interpreted as confirming a clinical diagnosis of endogenous depression. We found that serum dexamethasone concentrations in this test vary widely and are determinants of the DST response: non-suppression of serum cortisol levels is associated with low serum dexamethasone concentrations, and suppression is associated with high concentrations.


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S. Watson, P. Gallagher, J. C. Ritchie, I. N. Ferrier, and A. H. Young
Hypothalamic-pituitary-adrenal axis function in patients with bipolar disorder
The British Journal of Psychiatry, June 1, 2004; 184(6): 496 - 502.
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Copyright © 1986 The Royal College of Psychiatrists.