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The British Journal of Psychiatry 146: 507-509 (1985)
© 1985 The Royal College of Psychiatrists

Tritiated etorphine and naloxone binding to opioid receptors in caudate nucleus in schizophrenia

F Owen, RC Bourne, M Poulter, TJ Crow, SJ Paterson and HW Kosterlitz

Opioid receptor binding sites were assessed in membrane preparations of caudate nucleus from post-mortem brains of controls and of patients with schizophrenia. There was no difference between the two groups in the total specific binding of 3H-etorphine or in its 'mu' and ('delta + kappa') components. Similarly, the binding of 3H-naloxone did not differ between patients and controls. It is concluded that a previous report of reduced opioid receptors in caudate of schizophrenics is unlikely to prove a consistent finding and that the results of the present study offer no support to the claim that there is a general disturbance in opiate mechanisms in schizophrenia.


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Copyright © 1985 The Royal College of Psychiatrists.