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The British Journal of Psychiatry 146: 498-502 (1985)
© 1985 The Royal College of Psychiatrists

Plasma cortisol levels in mania: associated clinical ratings and changes during treatment with haloperidol

JC Cookson, T Silverstone, S Williams and GM Besser

Plasma cortisol levels were elevated in a large proportion of samples from manic patients. Although a correlation was found between clinical ratings of the severity of mania and the degree of elevation of daytime cortisol levels, some patients with low clinical ratings had elevated cortisol levels. During treatment with haloperidol, cortisol levels returned to normal earlier that the clinical state. The underlying mechanisms are discussed.


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Copyright © 1985 The Royal College of Psychiatrists.