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The British Journal of Psychiatry 146: 474-480 (1985)
© 1985 The Royal College of Psychiatrists

Long-term depot maintenance of chronic schizophrenic out-patients: the seven year follow-up of the Medical Research Council fluphenazine/placebo trial. III. Relapse postponement or relapse prevention? The implications for long-term outcome

DA Curson, TR Barnes, RW Bamber, SD Platt, SR Hirsch and JC Duffy

The relapse and admission histories revealed a positive correlation between number of schizophrenic episodes and time on maintenance medication, probably reflecting severity of illness. Relapse rates after drug discontinuation rose to 45% within 13 months. There were no differences of predictive value between those relapsing on or off medication. The relationship between relapse rates, drug treatment, and social outcome is complex; antipsychotic drugs may postpone relapse, and frequent relapses might inhibit improvement in social performance long after florid symptoms have been controlled by medication.


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T. Burns, M. Fiander, and B. Audini
A Delphi Approach To Characterising 'Relapse' as Used in Uk Clinical Practice
International Journal of Social Psychiatry, September 1, 2000; 46(3): 220 - 230.
[Abstract] [PDF]




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Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1985 The Royal College of Psychiatrists.