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The British Journal of Psychiatry 146: 474-480 (1985)
© 1985 The Royal College of Psychiatrists
DA Curson, TR Barnes, RW Bamber, SD Platt, SR Hirsch and JC Duffy
The relapse and admission histories revealed a positive correlation between number of schizophrenic episodes and time on maintenance medication, probably reflecting severity of illness. Relapse rates after drug discontinuation rose to 45% within 13 months. There were no differences of predictive value between those relapsing on or off medication. The relationship between relapse rates, drug treatment, and social outcome is complex; antipsychotic drugs may postpone relapse, and frequent relapses might inhibit improvement in social performance long after florid symptoms have been controlled by medication.
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