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The British Journal of Psychiatry 146: 312-314 (1985)
© 1985 The Royal College of Psychiatrists

Zopiclone: a non-benzodiazepine hypnotic. Controlled comparison to temazepam in insomnia

D Wheatley

Zopiclone, a non-benzodiazepine hypnotic, was compared with temazepam in the treatment of 36 patients suffering from insomnia; the trial period was two weeks, with cross-over of medications at one week and a randomised order of administration. There were highly significant improvements with both drugs, as compared to the control period in respect of: sleep latency, number of times waking during the night, and quality and duration of sleep. The incidence of side-effects was very low. No significant between-drug differences were found in respect to any of the assessment measures or of the incidence of side-effects.


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A. M. Holbrook, R. Crowther, A. Lotter, C. Cheng, and D. King
Meta-analysis of benzodiazepine use in the treatment of insomnia
Can. Med. Assoc. J., January 1, 2000; 162(2): 225 - 233.
[Abstract] [Full Text] [PDF]


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Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1985 The Royal College of Psychiatrists.