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The British Journal of Psychiatry 145: 591-599 (1984)
© 1984 The Royal College of Psychiatrists

The DST and its relationship to psychiatric diagnosis, symptoms and treatment outcome

HE Klein, W Bender, H Mayr, A Niederschweiberer and M Schmauss

The dexamethasone suppression test (DST) was administered shortly after admission to 102 consecutive in-patients with a Hamilton depression score greater than or equal to 16. Post-dexamethasone cortisol exceeded 6 micrograms/dl in 16 cases, and levels correlated significantly with Hamilton scores; with the AMP syndromes 'hypochondria', 'apathy' and 'catatonia'; and with the IMPS 'retarded depressive' syndrome. The criterion of suppression/non-suppression did not distinguish significantly between diagnostic categories (RDC or ICD), nor between endogenous and neurotic depression. (Newcastle scale). Both base-line and post-dexamethasone cortisol levels were reduced by prior treatment with minor tranquillisers, but not by major tranquillisers or antidepressants. DST results cannot be used as straightforward indicators of prognosis.


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J. C. Nelson and J. M. Davis
DST Studies in Psychotic Depression: A Meta-Analysis
Am J Psychiatry, November 1, 1997; 154(11): 1497 - 1503.
[Abstract] [Full Text]


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