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The British Journal of Psychiatry 144: 25-27 (1984)
© 1984 The Royal College of Psychiatrists

High-dose neuroleptics: uncontrolled clinical practice confirms controlled clinical trials

P Bollini, A Andreani, F Colombo, C Bellantuono, P Beretta, A Arduini, T Galli and G Tognoni

The strategy of high-dose intramuscular haloperidol as routinely applied in a general hospital psychiatric ward to 74 successive patients, 33 of whom stayed only up to seven days, and a further 34 up to 15 days, led to a complete recovery in only six, and complete lack of change in 23. Adverse reactions were recorded in 42, severe enough to stop treatment in eight; there were three deaths. In view of this risk-benefit analysis, systematic application of this high dose strategy to get a more rapid turnover of patients is unjustified.


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F.W.A. Browne, S.J. Cooper, R. Wilson, and D.J. King
Serum haloperidol levels and clinical response in chronic, treatment-resistant schizophrenic patients
J Psychopharmacol, January 1, 1988; 2(2): 94 - 103.
[Abstract] [PDF]


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Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1984 The Royal College of Psychiatrists.