BJP College Seminars Series
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Carter, S. B.
Right arrow Articles by Bridges, P. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Carter, S. B.
Right arrow Articles by Bridges, P. K.

The British Journal of Psychiatry 132: 125-132 (1978)
© 1978 The Royal College of Psychiatrists

Decreased urinary output of tyramine and its metabolites in depression

SB Carter, M Sandler, BL Goodwin, P Sepping and PK Bridges

Despite dramatic clinical improvement in about one-third of a group of severely depressed, medication-resistant patients one year after modified leucotomy, their relative decrease in conjugated and free tyramine output after an oral tyramine load remained unchanged and abnormal. Whilst a direct deficit in intestinal tyramine-conjugating ability still needs to be finally ruled out, this appears most compatible with a deficit due to bodily metabolic failure, perhaps a deficit in membrane transport which could be an essential aspect of the depressive illness syndrome. Attention is drawn to a similar defect in migraine. The two illnesses may represent a common predisposition which an appropriate triggering mechanism may transform to the florid disease. Biochemical detection of such vulnerability may have important diagnostic and predictive significance.


This article has been cited by other articles:


Home page
 J PsychopharmacolHome page
A.S. Hale, R. Hannah, M. Sandler, and V. Glover
Detoxified alcoholics, major depressives and tyramine sulphate excretion
J Psychopharmacol, January 1, 1995; 9(4): 386 - 389.
[Abstract] [PDF]

Home page
 J PsychopharmacolHome page
M. Sandler and D. Healy
The place of chemical pathology in the development of psychopharmacology
J Psychopharmacol, January 1, 1994; 8(2): 124 - 133.
[PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1978 The Royal College of Psychiatrists.