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The British Journal of Psychiatry 129: 342-345 (1976)
© 1976 The Royal College of Psychiatrists

Mianserin hydrochloride: a novel antidepressant

A Coppen, R Gupta, S Montgomery, K Ghose, J Bailey, B Burns and JJ de Ridder

The antidepressant activities of mianserin hydrochloride were investigated and compared with those of amitriptyline. The therapeutic efficacy of the two drugs appeared similar, but the incidence of side- effects was significantly higher with amitriptyline. Plasma levels of mianserin were determined during the trial and were not related to the therapeutic activity of the drug.


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C. BARBUI and M. HOTOPF
Amitriptyline v. the rest: still the leading antidepressant after 40 years of randomised controlled trials
The British Journal of Psychiatry, February 1, 2001; 178(2): 129 - 144.
[Abstract] [Full Text] [PDF]




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Copyright © 1976 The Royal College of Psychiatrists.