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The British Journal of Psychiatry 128: 494-498 (1976)
© 1976 The Royal College of Psychiatrists

A twin study of human red blood cell catechol-o-methyl transferase

L Grunhaus, R Ebstein, R Belmaker, SG Sandler and W Jonas

Significant sibling-sibling and within-family correlations of human red blood cell catechol-o-methyl transferase activity have suggested a high degree of genetic control over levels of activity of this catecholamine- related enzyme. However, family studies do not disentangle genetic from environmental similarities as causative of within-family correlations. We therefore undertook a human twin study using the monozygotic- dizygotic comparison method. Twelve pairs of monozygotic twins had an intraclass correlation of 90 in red blood cell catechol-o-methyl transferase activity, and seven pairs of dizygotic twins had an intraclass correlations of 37. Heritability of the enzyme activity was estimated by different methods as between 68-100 per cent.


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Copyright © 1976 The Royal College of Psychiatrists.