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The British Journal of Psychiatry (1974) 125: 310-315. doi: 10.1192/bjp.125.3.310
© 1974 The Royal College of Psychiatrists
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The Control of Deviant Sexual Behaviour by Drugs

I. Behavioural changes following Oestrogens and Anti-Androgens

JOHN BANCROFT M.D., M.R.C.P., M.R.C.Psych.1, GAVIN TENNENT D.M., M.R.C.Psych., Dip. Criminol.2, KYPROS LOUCAS B.Sc., M.R.C.S., M.R.C.Psych., D.P.M.3, and JAMES CASS S.R.N., R.M.N.4

1 First Assistant and Honorary Consultant Psychiatrist, Department of Psychiatry, University of Oxford, The Warneford Hospital, Oxford, OX3 7JX
2 Director, Special Hospitals Reseach Unit, Broadmoor Hospital, Crowthorne, Berks, Medical Director, St. Brendan's Hospital, Bermuda.
3 Consultant Psychiatrist, Broadmoor Hospital, Crowthorne, Berks
4 Charge Nurse, Broadmoor Hospital, Crowthorne, Berks

The effects of cyproterone acetate and ethinyl oestradiol on sexual behaviour of sexual offenders was assessed using a combination of behavioural, attitudinal and physiological measures. There was no significant difference between the drugs on any measure. They were equally effective in reducing frequency of sexual thoughts and sexual activity, whereas only cyproterone acetate produced a weak effect in reducing erectile and subjective responses to erotic stimuli. The possibility of a placebo effect cannot be excluded. On the dosages used, neither drug produced troublesome side effects. Further work is needed to assess the effects of longer administration and varying dose levels.

Submitted on September 19, 1973




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