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The British Journal of Psychiatry (1974) 125: 268-274. doi: 10.1192/bjp.125.3.268
© 1974 The Royal College of Psychiatrists
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The Relation of Blood Adenosine Triphosphate to Changes of Mood in Affective Disorders

OTTO HANSEN Fil. Dr.1 and MARIA DIMITRAKOUDI 2

1 Senior Visiting Scientist, Medical Research Council Unit for Metabolic Studies in Psychiatry, University Department of Psychiatry, Middlewood Hospital, P.O. Box 134, Sheffield, S6 1TP
2 Research Assistant in Psychiatry, Medical Research Council Unit for Metabolic Studies in Psychiatry, University Department of Psychiatry, Middlewood Hospital, P.O. Box 134, Sheffield, S6 1TP

In the light of previous findings in group studies of decreased blood ATP concentrations in psychotic depression (Hansen, 1972a, b), two manic-depressive women with predictable periodicity of illness were studied longitudinally with ATP determinations and mood rating. Again, ATP was found to be low in the depressive phases, and it correlated significantly with mood.

A male and a female `endogenous depressive' patient were followed with blood ATP determinations and mood rating during a course of electroconvulsive treatment. Correlating significantly with mood scores, ATP rose to normal with clinical recovery.

Submitted on September 3, 1973




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