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The British Journal of Psychiatry (1974) 125: 138-140. doi: 10.1192/bjp.125.2.138
© 1974 The Royal College of Psychiatrists
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Platelet Serotonin of Hyperactive School Age Boys

J. RAPOPORT M.D.1, P. QUINN M.D.2, N. SCRIBANU M.D.3, and D. L. MURPHY M.D.4

1 Asst. Prof., Pediatrics and Psychiatry, Georgetown U. Hosp., Washington, D.C. 20007
2 Fellow in Pediatrics, Georgetown U. Hosp., Washington, D.C. 20007
3 Asst. Prof., Pediatrics, Georgetown U. Hosp., Washington, D.C. 20007
4 Chief, Clinical Research Unit, Section on Psychiatry, Laboratory of Clinical Science, NIMH, Bethesda, Md. 20014

Platelet serotonin content did not differ between a group of 39 hyperactive boys and 19 age-matched normal controls. Imipramine treatment markedly reduced platelet serotonin, while methylphenidate had no similar effects. As both drugs were clinically effective, it seems unlikely that change in serotonin transport or storage is closely related to the mechanism of actions of these drugs on hyperactive behaviour.

Submitted on July 30, 1973




This article has been cited by other articles:


Home page
 Arch Gen PsychiatryHome page
S. M. Stahl
The Human Platelet: A Diagnostic and Research Tool for the Study of Biogenic Amines in Psychiatric and Neurologic Disorders
Arch Gen Psychiatry, May 1, 1977; 34(5): 509 - 516.
[Abstract] [PDF]


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Copyright © 1974 The Royal College of Psychiatrists.