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The British Journal of Psychiatry (1974) 125: 73-78. doi: 10.1192/bjp.125.1.73
© 1974 The Royal College of Psychiatrists
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Once versus Thrice Daily Thiothixene in the Treatment of Schizophrenic In-Patients

J. HILLARY LEE Ph.D.1, MARC BRANCHEY M.D.1, E. JANET HAHER R.N., B.S.1, ERVIN VARGA M.D., M.R.C.Psych.1, and GEORGE M. SIMPSON M.B., Ch.B., M.R.C.Psych.1

1 Research Center, Rockland State Hospital, Orangeburg, N.Y. 10962, U.S.A.

Thirty-eight chronic schizophrenic in-patients participated in a double blind crossover comparison of once-daily versus thrice-daily administered thiothixene. The once-daily dose was given at bed-time. Improvement over the placebo baseline occurred with both regimens though it appeared somewhat sooner with the multiple dosage regimen. During the final maintenance phase of the trial there was no difference between the regimens. Extrapyramidal side effects were consistently more marked with the multiple dosage regimen, though the difference reached statistical significance on only a few occasions. The practical applications of these findings are discussed, particularly in terms of maintenance therapy for both in-patients and out-patients and of the possibility of improving prescription compliance in the latter.

Submitted on August 13, 1973




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