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The British Journal of Psychiatry (1974) 124: 482-484. doi: 10.1192/bjp.124.5.482
© 1974 The Royal College of Psychiatrists
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Effects of Hypnotics on Anxious Patients

ANN MALPAS Ph. D.1, N. J. LEGG M.R.C.P.2, and D. F. SCOTT M.R.C.P., D.P.M.3

1 Lecturer, Department of Pharmacology and Therapeutics, London Hospital Medical College, London E1 1BB
2 Research Fellow, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX
3 Consultant in Charge EEG Department, Section of Neurological Sciences, The London Hospital, London E1 1BB

Hypnotics were given in courses lasting seven days to anxious patients in a double-blind placebo controlled study. The effects were assessed weekly on subjective, behavioural and EEG ratings. After a course of drug, but not of placebo, the EEG showed impairment in terms of drowsiness and sleep. Anxious patients appear to have fewer persistent effects of hypnotics than the normals examined in an earlier investigation, a finding of considerable importance to psychiatric practice, and a starting point for future study on ambulant patients.

Submitted on May 3, 1973




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