BJP Mental Health Guidelines from NICE
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
QUICK SEARCH:   [advanced]


     

The British Journal of Psychiatry (1974) 124: 385-391. doi: 10.1192/bjp.124.4.385
© 1974 The Royal College of Psychiatrists
This Article
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by CRAWFORD, R.
Right arrow Articles by FORREST, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by CRAWFORD, R.
Right arrow Articles by FORREST, A.

Controlled Trial of Depot Fluphenazine in Out-patient Schizophrenics

ROBERT CRAWFORD M.B., Ch.B., D.P.M.1 and ALISTAIR FORREST M.D., M.R.C.P., F.R.C.P.E., F.R.C.Psych.2

1 Queen Mary Hospital, Hammer Springs, North Canterbury, New Zealand
2 Physician Superintendent, Gogarburn Hospital, Edinburgh EH12 9BJ

A double blind controlled trial lasting 40 weeks was carried out to determine the effect of maintenance therapy with phenothiazines in a population of schizophrenics in the community. The study took place in the setting of a Community Nursing Service. All patients received capsules and injections, but were divided into two groups. Group A received oral trifluoperazine capsules (Stelazine) and placebo injections, while Group B received placebo capsules and depot fluphenazine decanoate injections (Modecate). Group A had a withdrawal rate from the trial of 48.9 per cent and a readmission rate to hospital of 26.6 per cent. Group B had a withdrawal rate of 14.3 per cent and a readmission rate of o per cent. The differences just fail to reach statistical significance at the 5 per cent level, but there was an evident trend suggesting the injection regime was superior in preventing relapse. This trend was confirmed when the differences in the BPRS scores were subjected to statistical analysis (significant at per cent level). Considerable bias operated in drawing the sample, and the ways in which this might have affected outcome have been discussed. The progress of all patients attending the hospital Modecate Clinic, from whom the trial population was drawn, was followed over the trial period. Readmission rate for those patients who were excluded from the trial because of problems associated with precarious prognosis, was 30.2 per cent.

Submitted on December 18, 1972




This article has been cited by other articles:


Home page
 Psychiatr. Serv.Home page
S. J. Keith, L. Pani, B. Nick, R. Emsley, L. San, M. Turner, R. Conley, P. Scully, P. S. Chue, and B. Lachaux
Practical Application of Pharmacotherapy With Long-Acting Risperidone for Patients With Schizophrenia
Psychiatr Serv, September 1, 2004; 55(9): 997 - 1005.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
F. Quitkin, A. Rifkin, J. Kane, J. R. Ramos-Lorenzi, and D. F. Klein
Long-Acting Oral vs Injectable Antipsychotic Drugs in Schizophrenics: A One-Year Double-Blind Comparison in Multiple Episode Schizophrenics
Arch Gen Psychiatry, July 1, 1978; 35(7): 889 - 892.
[Abstract] [PDF]

Home page
 Arch Gen PsychiatryHome page
P. Simon, J. Fermanian, D. Ginestet, M.-A. Goujet, and P. Peron-Magnan
Standard and Long-Acting Depot Neuroleptics in Chronic Schizophrenics: An 18-Month Open Multicentric Study
Arch Gen Psychiatry, July 1, 1978; 35(7): 893 - 897.
[Abstract] [PDF]

Home page
 Arch Gen PsychiatryHome page
A. Rifkin, F. Quitkin, C. J. Rabiner, and D. F. Klein
Fluphenazine Decanoate, Fluphenazine Hydrochloride Given Orally, and Placebo in Remitted Schizophrenics: I. Relapse Rates After One Year
Arch Gen Psychiatry, January 1, 1977; 34(1): 43 - 47.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1974 The Royal College of Psychiatrists.