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The British Journal of Psychiatry (1974) 124: 299-305. doi: 10.1192/bjp.124.3.299
© 1974 The Royal College of Psychiatrists
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Sex Chromatin Anomaly in Chinese Females: Psychiatric Characteristics of XXX

MING TSO TSUANG M.D., Ph.D.1

1 Associate Professor of Psychiatry, University of Iowa College of Medicine, 500 Newton Road, Iowa City, Iowa 52242, U.S.A.

Sex chromatin studies were done on 614 female patients consecutively admitted to the psychiatric wards of two hospitals in Taipei. For comparison, 2,182 girls from a primary school in Taiwan were also studied. No significant abnormalities were found other than the presence of double sex chromatin. The rates of double sex chromatin for the psychiatric in patients (3 .3/1,000 ) and for the schoolgirls (0.5/1,000) are similar to those reported by others. Combining the results of the present study and those reported from other countries, the pooled figures show that the rate of 2.7 per 1,000 (48/18,010) for the psychiatric population is statistically different from that of 0.7 per 1,000 (11/15,789) for the general population (Fisher's exact test, 1 tail, p < .00001). This seems to indicate that females with double sex chromatin bodies are more predisposed to mental disease than are females in the general population. Brief case histories of the three females with double sex chromatin found in the present study are presented, and the psychiatric characteristics of cases with an XXX chromosome complement in this and other studies are discussed.

Submitted on May 7, 1973




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