BJP College Seminars Series
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
QUICK SEARCH:   [advanced]


     

The British Journal of Psychiatry (1974) 124: 280-287. doi: 10.1192/bjp.124.3.280
© 1974 The Royal College of Psychiatrists
This Article
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by GOTTFRIES, C. G.
Right arrow Articles by SUNDBÄRG, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by GOTTFRIES, C. G.
Right arrow Articles by SUNDBÄRG, G.

Cerebrospinal Fluid pH and Monoamine and Glucolytic Metabolites in Alzheimer's Disease

C. G. GOTTFRIES M.D.1, Å. KJÄLLQUIST M.D.2, U. PONTÉN M.D.2, B. E. ROOS M.D.3, and G. SUNDBÄRG M.D.4

1 Professor of Psychiatry, Department of Psychiatry, University Hospital, Umea, Sweden
2 Associate Professor, Department of Neurosurgery, University Hospital, Lund, Sweden
3 Pharmacologist, Department of Pharmacology, University of Göteborg, Sweden
4 Department of Neurosurgery, University Hospital, Lund, Sweden

5-hydroxyindoleacetic acid, homovanillic acid, lactate, pyruvate, pH and Pco2 were determined in lumbar cerebrospinal fluid from patients with Alzheimer's disease. Dementia was measured by means of rating scales. Previous findings of an impaired metabolism of dopamine and 5-hydroxytryptamine were confirmed and strengthened. There were small but significant increases of lactate and lactate/pyruvate ratio, indicating that cellular hypoxia may be present in Alzheimer's disease. The mean pH and Pco2, did not deviate significantly from values measured in normal individuals. The dementia variables correlated significantly with homovanillic acid, lactate and pH of the cerebrospinal fluid.

Submitted on March 22, 1973




This article has been cited by other articles:


Home page
 Arch NeurolHome page
A. D. Kay, S. Milstien, S. Kaufman, H. Creasey, J. V. Haxby, N. R. Cutler, and S. I. Rapoport
Cerebrospinal Fluid Biopterin Is Decreased in Alzheimer's Disease
Arch Neurol, October 1, 1986; 43(10): 996 - 999.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
S. R. Bareggi, M. Franceschi, L. Bonini, L. Zecca, and S. Smirne
Decreased CSF Concentrations of Homovanillic Acid and {gamma}-Aminobutyric Acid in Alzheimer's Disease: Age- or Disease-Related Modifications?
Arch Neurol, November 1, 1982; 39(11): 709 - 712.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Psychiatric Bulletin Advances in Psychiatric Treatment All RCPsych Journals
Copyright © 1974 The Royal College of Psychiatrists.