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The British Journal of Psychiatry (1974) 124: 265-272. doi: 10.1192/bjp.124.3.265
© 1974 The Royal College of Psychiatrists
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A Study of Refractory Cases of Depressive Illnesses and their Response to Combined Antidepressant Treatment

E. R. SETHNA M.B., B.S., M.R.C.P., M.R.C.Psych., D.T.M. & H.1

1 Consultant Psychiatrist, All Saints' Hospital, Lodge Road, Birmingham B18 5SD

Patients suffering from depressive illnesses which proved refractory to treatment by tricyclic antidepressants, MAOIs and ECT were collected for a trial on a combination of phenelzine and amitriptyline. The patients who had proved refractory to treatment were all found to be suffering from 'neurotic' depression with long-standing neurotic and personality disorders. Combined antidepressant therapy proved to be significantly more effective than the previous antidepressant treatment. Adverse reactions to combined antidepressants were no worse than to antidepressants used singly. The possible reasons for the adverse reactions reported in the literature are discussed, and the ways of preventing them are suggested.

Submitted on April 4, 1973




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Copyright © 1974 The Royal College of Psychiatrists.