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The British Journal of Psychiatry (1969) 115: 1175-1179. doi: 10.1192/bjp.115.527.1175
© 1969 The Royal College of Psychiatrists
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Physicians' Preferences in a Blind Trial of Imipramine and Amitriptyline

EVELYN REYNOLDS B.A.1, D. F. CRAGGS M.B., B.S., D.P.M.2, M. P. JOYSTON-BECHAL B.M., B.Ch., M.R.C.P., D.P.M.3, M. J. PRITCHARD M.B., B.Chir., M.R.C.P., D.P.M.4, P. H. TOOLEY M.D., F.R.C.P., D.P.M.5, and M. WEATHERALL M.A., D.M., D.Sc.6

1 Department of Pharmacology, The London Hospital Medical College, Turner Street E.1; Department of Psychology, West Ham College of Technology, Romford Road, London, E.15
2 Department of Psychiatry, The London Hospital, E.1; Hellingly Hospital, Hailsham, Sussex
3 Department of Psychological Medicine, The London Hospital, E.1; Shenley Hospital, near St. Albans, Herts.
4 Department of Psychiatry, The London Hospital Medical College, Turner Street, E.1
5 Department of Psychiatry, The London Hospital, E.1
6 Department of Pharmacology, The London Hospital Medical College, Turner Street, E.1; The Wellcome Research Laboratories, Beckenham, Kent

Thirty-six depressed out-patients were treated with either imipramine or amitriptyline at a standard dose of 50 mg. three times a day for one, or two, four-week periods. These medications were, respectively, the drugs of choice of the psychiatrists treating the patients. Each psychiatrist treated his patients with his preferred drug single blind and double blind, and with the alternative, non-preferred, drug double blind, one-third each. A comparison of the therapeutic efficacy of the two drugs under these three conditions was attempted by several evaluative procedures. These showed no significant differences according to preference, though fewer patients on single blind treatments continued on therapy beyond the second month. Psychiatrists were unable to discriminate between the two drugs at better than chance level. The first week of treatment appears to have been the period of greatest change in patients.

Submitted on May 16, 1968




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C. BARBUI and M. HOTOPF
Amitriptyline v. the rest: still the leading antidepressant after 40 years of randomised controlled trials
The British Journal of Psychiatry, February 1, 2001; 178(2): 129 - 144.
[Abstract] [Full Text] [PDF]


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